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We research mechanisms and treatments for HCM. Patients participate
in research if they wish.
Prior HCM publications of our group:
| 1. |
Sherrid M, DeLia E, Dwyer E. Oral disopyramide therapy
for obstructive hypertrophic cardiomyopathy. Am J Cardiol
1988;62:1085-1088.
Oral disopyramide
improves obstruction and decreases symptoms. Even
low doses with low serum levels cause a significant
reduction in gradient. |
|
| 2. |
Sherrid MV, Chu CK, Delia E, Mogtader A, Dwyer Jr. EM.
An echocardiographic study of the fluid mechanics of
obstruction in hypertrophic cardiomyopathy. J Am Coll
Cardiol 1993;22:816-25.
Systolic anterior
motion is caused by the pushing force of flow. After
mitral-septal contact, obstruction begets more obstruction.
 |
 |
 |
 |
| Coaptation |
Just Before
Contact |
Contact |
After
Contact |
|
|
| 3. |
Sherrid MV, Gunsburg D, Pearle G: Mid-systolic drop
in left ventricular ejection velocity in obstructive
hypertrophic cardiomyopathy. The lobster claw abnormality.
Journal American Society of Echocardiography. 1997;10:707-12.
Mid-systolic drop
in left ventricular ejection velocity is due to true
obstruction to ventricular emptying. |
|
| 4. |
Sherrid MV, Pearle G, Gunsburg D. The mechanism of benefit
of negative inotropes in obstructive hypertrophic cardiomyopathy.
Circulation 1998; 97: 41-47.
Negative inotropes
decrease systolic ejection acceleration, delaying
systolic anterior motion. |
|
| 5. |
Sherrid MV. Dynamic left ventricular outflow obstruction
in hypertrophic cardiomyopathy revisited: Significance,
pathogenesis and treatment. Cardiology in Review 1998;
6: 135-145.
Review article
|
|
| 6. |
Sherrid M, Gunsburg D, Sharma A: Medical treatment of
hypertrophic cardiomyopathy. Current Cardiology Reports
2000; 2: 148-153. |
|
| 7. |
Sherrid M, Gunsburg DZ, Moldenhauer S, Pearle G: Systolic
anterior motion of the mitral valve begins at low left
ventricular outflow tract velocity in obstructive hypertrophic
cardiomyopathy. Journal of the American College of Cardiology
2000; 36: 1344-1354. |
| |
|
| 8. |
Sherrid M, Chaudhry FA, Swistel DG. Obstructive
Hypertrophic Cardiomyopathy: Echocardiography, Pathophysiology,
and the Continuing Evolution of Surgery for Obstruction.
Annals of Thoracic Surgery 2003;75:620-32. |
| |
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| 9. |
Maron B, Carney K, Lever H, Lewis J, Barac
I, Casey S, Sherrid M: Relationship of race to sudden
cardiac death in competitive athletes with hypertrophic
cardiomyopathy. Journal of the American College of Cardiology
2003;41:974-80. |
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