Research and Publications

We research mechanisms and treatments for HCM. Patients participate in research if they wish.

Prior HCM publications of our group:

Original Peer Review Articles:

  1. Sherrid MV, Shetty A, Winson G, Kim B, Musat D, Alviar CL, Homel P, Balaram SK, Swistel DG. Treatment of obstructive hypertrophic cardiomyopathy symptoms and gradient resistant to first-line therapy with beta-blockade or verapamil. Circulation: Heart Failure 2013;6:694-702.

  2. Ro, R, Halpern D, Sahn DJ, Homel P, Arabadjian M, Lopresto C, Sherrid MV. Vector flow mapping in obstructive hypertrophic cardiomyopathy to assess the relationship of early systolic left ventricular flow and the mitral valve. J Am Coll Cardiol 2014;64;1984-95.

  3. Sherrid MV, Arabadjian M, Koulova A. Thin-filament mutations, hypertrophic cardiomyopathy, and risk. Editorial. J Am Coll Cardiol 2014;64:2601-4.

  4. Argulian E, Messerli FH, Aziz EF, Winson G RN, Agarwal V, Kaddaha F, Kim B, Sherrid MV. Antihypertensive therapy in hypertrophic cardiomyopathy. American Journal of Cardiology 2013;111:1040-45.

  5. Sherrid M. The implanted cardioverter-defibrillator for children and adolescents with high risk of sudden death from hypertrophic cardiomyopathy. Editorial. Journal of the American College of Cardiology 2013;61:1536-8.

  6. Feiner E, Arabadjian M, Winson G, Kim B, Chaudhry F, Sherrid MV. Postprandial upright exercise echocardiography in hypertrophic cardiomyopathy. Journal of the American College of Cardiology 2013;61:2487-88.

  7. Alhaj EK, Kim B, Cantales D, Uretsky U, Chaudhry FA, Sherrid MV. Symptomatic exercise-induced left ventricular outflow tract obstruction without left ventricular hypertrophy. Journal of the American Society of Echocardiography 2013;26:556-565.

  8. Joshi S, Patel UK, Yao SS, Castenada V, April I, Winson G, Chaudhry FA, Sherrid MV. Standing and exercise Doppler echocardiography in obstructive hypertrophic cardiomyopathy: The range of gradients with upright activity. Journal of the American Society of Echocardiography 2011;24:75-82.

  9. Balaram SK, Ross RE, Sherrid MV, Schwartz GS, Hillel Z, Winson G, Swistel DG. Role of mitral valve plication in the surgical management of hypertrophic cardiomyopathy. Ann Thorac Surg 2012;94:1990-1998.

  10. Sherrid MV, Cotiga D, Hart D, Ehlert FA, Haas TS, Shen WK, Link MS, Estes III NAM, Epstein AE, Semsarian C, Daubert JP, Winters SL, Giudici MC, Maron BJ. Relation of 12-Lead electrocardiogram patterns to implanted defibrillator-terminated ventricular tachyarrhythmias in hypertrophic cardiomyopathy. Am J Cardiol 2009;104:1722-26.

  11. Minami Y, Kajimoto K, Kawana M, Hagiwara N, Sherrid MV. Synergistic effect of dual chamber pacing and disopyramide in obstructive hypertrophic cardiomyopathy. International Journal of Cardiology 2010;41:195-197.

  12. Shah A, Duncan K, Winson G, Chaudhry FA, Sherrid MV. Severe symptoms in mid and apical hypertrophic cardiomyopathy. Echocardiography 2009; 26:922-33.

  13. Sherrid, MV, Wever-Pinzon O, Shah A, Chaudhry FA. Reflections of inflections in hypertrophic cardiomyopathy. Journal of the American College of Cardiology 2009; 212-219.

  14. Balaram SK, Tyrie L, Sherrid MV, Afthinos J, Hillel Z, Winson G, Swistel DG. Resection-Plication-Release for hypertrophic cardiomyopathy: Clinical and echocardiographic follow-up. Ann Thorac Surg 2008;86:1539-45.

  15. Barac I, Upadya S, Pilchik R, Winson G, Passick M, Chaudhry FA, Sherrid MV. Effect of obstruction on longitudinal left ventricular shortening in hypertrophic cardiomyopathy. J Am Coll Cardiology 2007;49: 1203-1211.

  16. Maron BJ, Spirito P, Shen WK, Haas TS, Formisano F, Link MS, Epstein AE, Almquist AK, Daubert JP, Lawrenz T, Boriani G, Estes NA 3rd, Favale S, Piccininno M, Winters SL, Santini M, Betocchi S, Arribas F, Sherrid MV, Buja G, Semsarian C, Bruzzi P. Implantable cardioverter-defibrillators and prevention of sudden cardiac death in hypertrophic cardiomyopathy. JAMA. 2007;298:405-412.

  17. Sherrid MV, Mahenthiran J, Casteneda V, Fincke R, Gasser M, Barac I, Thayaparan R, Chaudhry F. Comparison of diastolic septal perforator flow velocities in hypertrophic cardiomyopathy vs. hypertensive left ventricular hypertrophy. American Journal of Cardiology 2006;97:106-112.

  18. Balaram SK, Sherrid MV, DeRose JJ, Hillel Z, Winson G, Swistel DG. Beyond extended myectomy for hypertrophic cardiomyopathy: The RPR (Resection-Plication-Release) Repair. Annals of Thoracic Surgery 2005;80: 217-223.

  19. Sherrid MV, Barac I, McKenna WJ, Elliott PM, Shaughan Dickie, Chojnowska L, Casey S, Maron B. Multicenter study of the efficacy and safety of disopyramide in obstructive hypertrophic cardiomyopathy. J Am Coll Cardiology 2005;45:1251-8.

  20. Arad M, Penas-Lado M, Monserrat L, Maron BJ, Sherrid M, Ho CY, Barr S, Karim A, Olson TM, Kamisago M, Seidman JG, Seidman CE. Gene mutations in apical hypertrophic cardiomyopathy. Circulation 2005;112:2805-11.

  21. Swistel DG, DeRose JJ, Sherrid MV. Management of patients with complex hypertrophic cardiomyopathy. Resection/ Plication/ Release. Operative Techniques in Thoracic and Cardiovascular Surgery, A Comparative Atlas 2004;9:261-267.

  22. Sherrid M, Chaudhry FA, Swistel DG. Obstructive Hypertrophic Cardiomyopathy. Echocardiography, Pathophysiology, and the Continuing Evolution of Surgery for Obstruction. Annals of Thoracic Surgery 2003;75:620-32.

  23. Maron B, Carney K, Lever H, Lewis J, Barac I, Casey S, Sherrid M. Relationship of race to sudden cardiac death in competitive athletes with hypertrophic cardiomyopathy. Journal of the American College of Cardiology 2003;41:974-80.

  24. Sherrid M, Gunsburg DZ, Moldenhauer S, Pearle G. Systolic anterior motion begins at low left ventricular outflow tract velocity in obstructive hypertrophic cardiomyopathy. Journal of the American College of Cardiology 2000;36:1344-1354.

  25. Sherrid M, Pearle G, Gunsburg DZ. The mechanism of benefit of negative inotropes in obstructive hypertrophic cardiomyopathy. Circulation 1998;97: 41-47.

  26. Sherrid M, Gunsburg DZ, Pearle G. Mid-systolic drop in left ventricular ejection velocity in obstructive hypertrophic cardiomyopathy - the lobster claw abnormality. Journal of the American Society of Echocardiography 1997;10: 707-712.

  27. Sherrid M, Chu CK, DeLia E, Mogtader A, Dwyer E. An echocardiographic study of the fluid mechanics of obstruction in hypertrophic cardiomyopathy. Journal of the American College of Cardiology, 1993; 22: 816-825.

  28. Sherrid M., Delia E, Dwyer E. Oral disopyramide therapy for obstructive hypertrophic cardiomyopathy. The American Journal of Cardiology, 1988; 62: 1085-1088.

Case Reports

  1. Frisoli TM, Swistel DG, Makani H, Sherrid MV. Wretched excess: Cathartic abuse and cardiogenic shock in the setting of obstructive hypertrophic cardiomyopathy. American Journal of Medicine 2013;126:773-775.

  2. Sherrid MV, Balaran SK, Korzeniecki E, Chaudhry FA, Swistel DG.

  3. Reversal of acute systolic dysfunction and cardiogenic shock in hypertrophic cardiomyopathy by surgical relief of obstruction. Echocardiography 2011,28:E174-179.

  4. Maron BJ, Sherrid MV, Haas TS, Lindberg J, Kitner C, Lesser JR. Novel hypertrophic cardiomyopathy phenotype: segmental hypertrophy isolated to the posterobasal left ventricular wall. Am J Cardiol 2010;106:750-752.

  5. Sirak T, Sherrid MV. Oral disopyramide for the acute treatment of severe outflow obstruction in hypertrophic cardiomyopathy in the ICU setting. Chest 2008;133:1243-46.

  6. Duncan K, Shah A, Chaudhry F, Sherrid MV. Hypertrophic cardiomyopathy with massive midventricular hypertrophy, midventricular obstruction and an akinetic apical chamber - Case Report. Anatolian Journal of Cardiology 2006;6:279-82.

Review Articles and Book Chapters

  1. Halpern DG, Sherrid MV. Echocardiography in hypertrophic cardiomyopathy. In Nanda N, ed. Comprehensive Textbook of Echocardiography. New Delhi: JP Medical; 2013:1348-1368.

  2. Sherrid M. Pharmacologic Therapy of Hypertrophic Cardiomyopathy. Current Cardiology Reviews 2015. Accepted for publication.

  3. Sherrid MV, Arabadjian M. A primer of disopyramide treatment of obstructive hypertrophic cardiomyopathy. Progress in Cardiovascular Disease 2012;54:483-492.

  4. Sherrid MV, Arabadjian M. Echocardiography to individualize treatment for hypertrophic cardiomyopathy. Progress in Cardiovascular Disease 2012;54:461-476.

  5. Musat DL, Marineci S, Sherrid MV. Can pharmacologic gradient reduction decrease mortality in hypertrophic cardiomyopathy? Progress in Cardiovascular Disease 2012;54:535-542.

  6. Myerson M, Sanchez-Ross M, Sherrid MV. Pre-participation athletic screening for genetic heart disease. Progress in Cardiovascular Disease 2012;54:543-552.

  7. Joshi R, Sherrid MV. Hypertrophic cardiomyopathy. In Herzog E, ed. The CCU Survival Guide. Philadelphia: Lippincott Williams & Wilkins 2012:121-130.

  8. Wever-Pinzon OE, Myerson M, Sherrid MV. Sudden cardiac death in young competitive athletes due to genetic cardiac abnormalities. Anatolian Journal of Cardiology 2009;9 Suppl 2:17-23.

  9. Kamath GS, Mittal S, Sherrid MV. Selective implantation of cardioverter-defibrillators in patients with genetic heart disease and sudden death risk. Anatolian Journal of Cardiology 2009;9 Suppl 2:32-40.

  10. Sherrid MV, Daubert JP. Risks and challenges of implantable cardioverter-defibrillators in young adults. Progress in Cardiovascular Diseases 2008;51: 237-263.

  11. Sherrid MV, Sirak T. Hypertrophic cardiomyopathy: individualized therapy for a heterogeneous disease. Minerva Cardioangiologica 2008;56:671-92.

  12. Sherrid M. Pathophysiology and treatment of hypertrophic cardiopathy. Progress in Cardiovascular Disease 2006; 49:123-151.

  13. Musat D, Sherrid M. Pathophysiology of hypertrophic cardiomyopathy determines its medical treatment. Anatolian Journal of Cardiology. 2006; 6:9-17.

  14. Sherrid M. Hypertrophic cardiomyopathy: through a window of 50 years. (editorial) Anatolian Journal of Cardiology. 2006; 6:1-2.

  15. Musat D, Sherrid M. Echocardiography in the treatment of hypertrophic cardiomyopathy. Anatolian Journal of Cardiology. 2006; 6:18-26.

  16. Cotiga D, Ehlert F, Sherrid M. Syncope, other risk factors, and the implantable defibrillator for sudden death prevention in hypertrophic cardiomyopathy. Anatolian Journal of Cardiology. 2006; 6:55-60.

  17. Kukar A, Sherrid MV, Ehlert FA. Pacing in obstructive hypertrophic cardiomyopathy: a therapeutic option? Anatolian Journal of Cardiology. 2006; 6:49-54.

  18. Sherrid M, Barac I. Pharmacologic treatment of symptomatic hypertrophic cardiomyopathy. Maron BJ, ed. Diagnosis and Management of Hypertrophic Cardiomyopathy. Boston MA: Blackwell- Futura. 2004:200-219.

  19. Sherrid M, Gunsburg D, Sharma A. Medical treatment of hypertrophic cardiomyopathy. Current Cardiology Reports 2000;2: 148-153.

  20. Sherrid M. Dynamic left ventricular outflow obstruction in hypertrophic cardiomyopathy revisited: significance, pathogenesis and treatment. Cardiology in Review 1998;6:135-145.